{"created":"2023-06-19T12:16:02.304495+00:00","id":216,"links":{},"metadata":{"_buckets":{"deposit":"7ee203ec-0f91-4fe8-a2e9-0ab187d1856c"},"_deposit":{"created_by":24,"id":"216","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"216"},"status":"published"},"_oai":{"id":"oai:hachinohe-hachitan.repo.nii.ac.jp:00000216","sets":["248:325"]},"author_link":["326","332"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"49","bibliographicPageEnd":"45","bibliographicPageStart":"37","bibliographic_titles":[{"bibliographic_title":"八戸学院大学紀要"}]}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"近年、免疫グロブリンを伴わない補体成分C3 の糸球体沈着を診断の基準としたC３腎症という新たな疾患概念が提唱されている。各種腎疾患の組織傷害においては補体活性化反応の関与が考えられるが、C3 腎症では補体第二経路の制御異常がその発症の主要なメカニズムであることが示されており、遺伝的および後天的背景についての検討が進められている。さらに、新たな治療として過度の補体活性化反応を抑制する抗補体薬の使用が試みられてきている。今後、明確にされるべき課題も多く残されているが、難治性とされる疾患の治療戦略に病因を考慮したアプローチが加わることで予後改善への可能性が大いに期待される。","subitem_description_type":"Other"}]},"item_10002_select_24":{"attribute_name":"論文種別","attribute_value_mlt":[{"subitem_select_item":"原著論文"}]},"item_10002_select_25":{"attribute_name":"学部学科","attribute_value_mlt":[{"subitem_select_item":"人間健康学部人間健康学科"}]},"item_10002_select_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_select_item":"八戸学院大学"}]},"item_10002_select_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_select_item":"2187-8102"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"遠藤, 守人"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大澤, 勲"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-12-24"}],"displaytype":"simple","filename":"C3 腎症の概念とその病態.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PDF(本文)","url":"https://hachinohe-hachitan.repo.nii.ac.jp/record/216/files/C3 腎症の概念とその病態.pdf"},"version_id":"60ecb6db-285b-4230-8ee7-4670e979a28e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"C3 腎症","subitem_subject_scheme":"Other"},{"subitem_subject":"膜性増殖性糸球体腎炎","subitem_subject_scheme":"Other"},{"subitem_subject":"補体第二経路","subitem_subject_scheme":"Other"},{"subitem_subject":"抗補体薬","subitem_subject_scheme":"Other"},{"subitem_subject":"C3 glomerulopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Membranoproliferative glomerulonephritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Complement alternative pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anticomplement therapies","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"C3 腎症の概念とその病態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C3 腎症の概念とその病態"},{"subitem_title":"Cuurent concepts in C3 glomerulopathy","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"24","path":["325"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"216","relation_version_is_last":true,"title":["C3 腎症の概念とその病態"],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-19T12:42:06.788744+00:00"}